Expertise and Current Research Activity
My research involves novel ways of formulating and delivering to the body, problematic drug candidates, especially drugs used to treat cancer and AIDs. I am also the inventor or co-inventor of the drugs fosphenytoin (Cerebyx®), Viread®, Lusedra® and Captisol® the solubilizer used in the injectable forms of Vfend®, Geodon®, Abilify®, Nexterone® and the veterinary product Cerenia® and helped formulate the novel anticancer drug Velcade®.
I helped found three Kansas companies, Cydex Pharma, Crititech and ProQuest Pharma. All of the products are helping Kansans and others throughout the world live healthy and productive lives. I also helped establish the biosciences incubator in Lawrence and I am involved with the National Cancer Center designation for the University of Kansas.
Ph.D., Analytical Pharmaceutical Chemistry and Pharmaceutics, University of Kansas
B. Pharm., Victorian College of Pharmacy
General research interests might be defined as the application of physical organic chemistry to solving pharmaceutical problems (prodrugs, drug stability, biopharmaceutics and pharmacokinetics, especially as they relate to prodrugs, dissolution and other phase transport phenomena, etc. Specifically:
2. Novel drug delivery systems.
3. Preformulation studies on parenteral cytotoxic and antiAIDs drugs.
4. Development and assessment of novel, modified cyclodextrins.
5. Sulfenamides as prodrugs.
6. Novel peroxide scavengers
- Drug stability
- Drug formulation